Review Article: Potential Molecular Pathway on Herbal Plants for Aging Skeletal Muscle Health
Kata Kunci:
Herbal, Sarcopenia, Aging, Skeletal muscleAbstrak
Sarcopenia is one of the major clinical problems for the elderly and its significant increase number of in expanding research in this area. Precise cellular and molecular mechanism pathway contribution to sarcopenia is still uncertain and involves multifactorial processes such as alteration of physical activity, oxidative stress, nutritional intake, and hormonal changes. There is extensive enormous interest in exploring the potential of herbal supplements to preserve or promote muscle mass in sarcopenia since traditional herbal compounds and formulas are generally cheaper, less toxic and have fewer side effects. This review aims to outline the possible molecular and cellular pathway that may be affected by the herbal and botanical compound. The molecular signaling, pathway involved protein synthesis (IGF-1, PI3-K, Akt, mTOR), muscle regeneration (TGFβ and Myostatin), protein degradation (Ubiquitin-Proteasome System and Autophagy signalling, pathways), inflammation (TNFα and NF-κB) and mitochondrial biogenesis (PGC-1α and AMPK) were identified in this review as potential molecular pathways that affected in vary herbal supplementation. Herbal supplements have shown an ability to affect more than one molecular pathway.
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